Tuberculous ulcer of the skin.

an augmented risk, because the most effective therapy cannot be used. Although the importation of chloramphenicol-resistant S. typhi is undesirable it need not arouse alarm in Britain, because opportunities for the spread of typhoid in this country are negligible. Nevertheless, if epidemics caused by chloramphenicol-resistant S. typhi occur on a sufficiently large scale in countries of high typhoid incidence, such organisms may spread to other countries often enough to present an irksome problem, and the possibility of residual carriers of these imported strains cannot be discounted. The British cases of typhoid infected in Mexico, and the epidemic which caused them, are a warning of this, and are a reminder that if antibiotics such as chloramphenicol are to retain their efficacy for important diseases, their use should be largely if not entirely restricted to those diseases throughout the world. References